Structural Biology

A person wearing blue gloves and a white protective suit operates a piece of laboratory equipment called a "mosquito." The machinery appears to be handling a transparent lab tray, indicating its use in bioanalytical development or preclinical ADME studies.

Structural Biology Services

Pharmaron’s structural biology services provide the visualization of how your compound and target will interact, allowing for a more efficient and effective design-synthesis-testing cycle.

This capability is established through a robust process that includes quick plasmid generation, cell line generation, protein expression and purification followed by the complexing with small molecules to generate crystals of protein/small molecule complexes and their structure determination.

A lab setup features a Formulatrix RI-54 machine with rows of samples inside, next to a Dell monitor displaying four circular petri dish images with white, fluffy microbial growth and data analysis. The equipment is situated in a clean, white workspace, ideal for bioanalytical development.

Gene to Protein Structure Determination

  • Plasmid creation and cell line generation
  • Protein expression and protein purification for in vitro assay and crystallization
  • Protein crystallization of novel or published targets
  • Crystal structure determination and analysis of novel or published targets
  • Generation of small molecule complexes with protein through soaking and/or co-crystallization