Antibody-drug Conjugates

Laboratory equipment with an open lid displays a digital interface showing temperature, speed, and time settings. Orange tube holders and test tubes used in antibody-drug conjugates research are placed inside.

Antibody-drug Conjugates (ADC) Services

Pharmaron can help our partners with the entire synthesis process of bioconjugates including linker drug generation to antibody expression and purification to bioconjugation. Pharmaron’s team has years of experience generating high potency payloads as well as linker payloads from discovery stage to GMP manufacturing.

Pharmaron’s team has built capabilities to express and purify protein as well as cell line optimization from discovery to process development stage and GMP services will be available next year.

Our integrated drug discovery approach allows our team to generate the bioconjugate and even test them in vitro and in vivo essay for efficacy, stability, PK and toxicology.

A gloved hand holds a small, clear vial filled with liquid, with numbers written on the label. The vial is being placed into or taken from a black, numbered holder with multiple circular compartments. This bioanalytical development setup is essential for precise measurements. The background is blurred.

Conjugation Chemistries

  • Via Cystine – Intrachain disulfides, site specific
  • Via Lysine

QC Packages

  • Concentration 
  • DAR
  • % monomer
  • Endotoxin level
  • % free payload present in final bulk
  • Peptide mapping

Laboratory Chemistry Services

Pharmaron provides efficient and innovative services in support of medicinal chemistry and drug discovery research.

Two scientists in protective gear work with specialized equipment in a controlled laboratory setting, conducting advanced chemistry experiments.