Tritium Radiosynthesis

A scientist performs Tritium radiosynthesis in an enclosed lab setup, wearing long protective gloves and controlling precise instrumentation.

Tritium Radiosynthesis Services

Pharmaron’s team of tritium experts work together with you to develop a radiolabelling strategy for the compound(s) and desired applications including late-stage lead optimization of candidate compounds. Our team provides advice on custom tritium-labelled compounds and optimal position(s) of the tritium [3H] label(s).

Tritium Radiosynthesis Techniques

  • Tritium gas exchange using modern heterogenous and homogeneous catalysts
  • Tritiated water exchange
  • Catalytic reduction with tritium gas
  • Reduction with [3H]Borohydride
  • Catalytic dehalogenation with tritium gas
  • Catalytic photoredox tritiation
  • High specific activity methylation using [methyl-3H]nosylate
  • Covalent tritium labelling of macromolecules using [3H]NSP
A scientist in protective gear handling tritium radiosynthesis materials inside a radiation safety cabinet, ensuring controlled conditions.

Specialized Tritium Labelling

  • Nucleotides, oligonucleotides
  • Peptides
  • Proteins
  • Antibodies, antibody-drug conjugates (ADCs)
  • Carbohydrates

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A scientist operates an advanced NMR spectrometer in a dimly lit lab, analyzing molecular structures, with a large magnetic instrument beside her.

Analytical Chemistry Support for Tritiated Compounds

  • Mass spectrometry (LC-MS/MS)
  • HPLC or UPLC (with UV and flow-through radio-detectors)
  • NMR (3H-NMR for identity, structural confirmation and position of 3H label)
  • Gas chromatography (GC)
  • FT-IR, DSC, TGA, KF
  • GLP compliance or GLP analysis (if required)