Inflammation, Immunology and Pain Models
Inflammation, Immunology & Pain Models for Efficacy Studies
Pharmaron provides efficacy testing services in inflammation models, immunology models, and pain models (inflammatory pain models and neuropathic pain models) offering comprehensive preclinical services for the evaluation of therapies targeting these complex diseases. The team is supported by internal PK/bioanalytical, ex vivo pharmacology, and in vitro biology teams to provide integrated services.
Highly-Skilled Animal Study Teams
Inflammation, immunology, and pain models require a high degree of scientific expertise to ensure accuracy and reproducibility in readouts such as animal behavior and physiological observations. Our teams provide the technical excellence and deep understanding of these models, ensuring reliable results.
Communication with One Point of Contact
We often receive positive feedback for our communication from clients. What do we differently? One dedicated study director is responsible for the entire study, from proposal to reporting. This approach ensures seamless communication, keeps clients informed with timely updates and ensures that study objectives are met with clarity and alignment.
Extensive Readout Options
Efficacy studies with inflammation, immunology and pain models require the right readouts to provide clients with a complete understanding of target engagement, pharmacologic activity of the compound, and interpretation of the treatment effects. Our platform covers physiological, cellular, molecular, histological and omics-based readouts to provide our clients a comprehensive picture of the study outcome.
Study Types
- Development and validation of disease models
- Maximum tolerated dose studies
- Dose range finding studies
- Efficacy studies
- PK/PD studies
Capabilities
Acute Inflammatory Models
Pharmaron’s acute inflammatory pain models are designed to assess pain-related responses driven by inflammation. These models provide critical insights into pain mechanisms, drug efficacy, and therapeutic potential, supporting the development of effective analgesics.
- Air pouch model
- LPS-induced cytokine release model
- R848-induced cytokine release model
- Delayed-Type hypersensitivity
- Passive cutaneous anaphylaxis (PCA)
- Mono iodoacetate (MIA)-induced rat model
- Tail flick model
Immunology and Autoimmune Disease Models
Pharmaron’s in vivo pharmacology team possesses a broad portfolio of validated immunology and autoimmune disease models for robust efficacy evaluation of test articles.
- Wound healing model
- Inflammatory bowel disease (IBD) model
- Asthma model
- Arthritis model
- Skin inflammation models (atopic dermatitis, psoriasis, alopecia, and more)
- Systemic lupus erythematosus model
- Type I diabetes animal model
Acute Inflammatory Pain Models
Our acute inflammatory pain models enable the exploration of inflammation-pathway mechanisms, providing insights into drug action and potency for therapeutic development.
- Carrageenan-induced paw edema
- Formalin test
- Complete Freund’s adjuvant (CFA) model
- Nerve growth factor (NGF) model
- Wound healing model
- Paw incision model
- Acetic acid (AcOH)-induced writhing model
- MSU-induced gout arthritis model
- Ocular inflammation models
Neuropathic Pain Models
Pharmaron’s in vivo pharmacology team offers a comprehensive range of neuropathic pain models to assess the efficacy of analgesics and neuroprotective agents.
- Chronic constriction injury model (CCI; Bennett model)
- Spared nerve injury (SNI) model
- Vincristine-induced peripheral neuropathic pain model
- Bortezomib-induced peripheral neuropathy pain model
- Paclitaxel-induced peripheral neuropathy pain model
- Cancer-induced bone pain(CIBP) model
- Nitroglycerin (NTG)-induced migraine rat model
Functional and Behavioral Endpoints
Molecular biomarkers alone cannot draw the full picture of biological processes when investigating inflammation, immunology or pain effects. Functional readouts add to the picture for evaluation of the therapeutic effects.
- Inflammation and edema: Paw volume, joint swelling, paw thickness
- Pain sensitivity: Tail flick test, von Frey filament test, hot plate test, cold plate test, Hargreaves test, weight bearing test, paw pressure, behavioral gait analysis
Biomarker and Bioanalysis Platforms
Our platforms to analyze disease-specific biomarkers and drug concentrations ensure clients receive actionable insights to understand target engagement, pharmacodynamic responses, and drug expose for meaningful study outcomes.
- Matrices: blood, tissue, urine, feces, other body fluids
- Drug concentration quantification
- Disease-specific biomarker analysis
- Gene and protein evaluations
- Flow cytometry
- Histology and IHC
- Hematology, blood chemistry, urinalysis, and coagulation
- Single-cell RNA-sequencing
Pharmaron’s integration of technology and expertise in inflammation, immunology, and pain models along with biomarker, bioanalysis and behavior platforms ensures comprehensive solutions, helping clients overcome research challenges and accelerate therapeutic advancements.
Related Resources Showcasing Efficacy Studies with Pharmaron’s Immunology, Inflammation and Pain Models
in vivo Mouse Model for Optic Neuropathy
Neuropathy Drug Testing via Cancer-induced Bone Pain Model
