Cell Line Development

Optimized Biologics Cell Line Development (CLD) Services

Pharmaron offers comprehensive Cell Line Development (CLD) solutions tailored for biologics, ensuring efficiency, quality, and scalability from the earliest stages of development. Our services support biologics production while maintaining the highest productivity and cell line stability standards.

Core Features of Our CLD Solutions

Our Cell Line Development (CLD) services drive biologics production with a focus on efficiency, stability, and scalability:

  • Advanced Screening: Using Solentim VIPS systems, we rapidly screen and select top clones with high precision
  • Monoclonality Assurance: Solentim CLD Metrics verifies monoclonality, ensuring compliance with regulatory standards
  • High-Throughput Bioreactors: Ambr 15 bioreactors optimize fed-batch development for scalable production
  • Regulatory Compliance: Our processes include secure PCB banking and testing for long-term regulatory success
A visual representation of the cell line development workflow, illustrating transgene transfection, clone screening, and quality analysis steps.

Streamlined CLD Workflow

Pharmaron’s Cell Line Development (CLD) process ensures efficient and scalable biologics production, from Vector Construction to final clone selection.

  • Vector Construction and Stable Transfection: Select a suitable vector, optimize codons, synthesize genes, construct a plasmid, and transfect cells
  • Pool Screening: High-throughput systems rapidly screen for high-expressing cell pools
  • Clone Screening: Identify and refine the top 10 clones using advanced screening and imaging technologies
  • Final Clone Selection: Imaging tools help select the top clones for productivity, quality, and stability
  • Regulatory-Ready PCB Banking: PCB banking and testing are performed with full regulatory compliance in mind, ensuring safe, scalable production
A scientist in full protective gear performs precise pipetting in a sterile lab environment, supporting advanced cell line development services (CLD).

Cutting-Edge Technologies Enhancing CLD

Pharmaron employs advanced technologies to enhance accuracy and scalability:

  • Precision Cell Screening: Solentim VIPS enables rapid, reliable single-cell isolation to streamline clone selection
  • Streamlined Process Scalability: High-performance Ambr 15 bioreactors enable seamless scale-up, ensuring consistent production
  • Regulatory-Ready Clonality Imaging: Innovative imaging systems verify monoclonality with precision, facilitating regulatory compliance
  • Advanced Analytics: We assess growth, expression, and product quality to meet the highest industry standards

Ready to Scale Your Biologics Production?

Pharmaron’s comprehensive Cell Line Development (CLD) workflow is designed to accelerate biologics development, from transgene transfection to large-scale production, ensuring regulatory compliance and long-term stability.

A scientist in sterile blue attire operates large bioprocess equipment in a cGMP drug substance manufacturing facility, managing tubing and machinery.