Peptide Synthesis Services
Pharmaron Delivers Fit‑for‑Purpose Peptide Synthesis Solutions
Pharmaron’s deep scientific expertise and global manufacturing scale helps innovator companies overcome peptide synthesis, scale‑up and CMC challenges with speed, quality and reproducibility. Our integrated peptide synthesis platform supports the full development lifecycle, from early discovery programs to clinical and commercial supply. By combining advanced chemistry, robust purification and regulatory‑ready manufacturing, Pharmaron provides reliable, scalable peptide solutions tailored to your program needs. Peptide and peptide libraries syntheses are offered from 2 to 50+ amino acids including complex linear/cyclic peptides on milligram to hundred grams scales.
Pharmaron’s peptide synthesis experience includes:
- Linear, cyclic, stapled peptides, and ‘click’ peptides
- Multi-UAA-containing sequences
- N- and C-terminal modifications
- Biotinylated and fluorescent-labeled peptides
- Conjugation precursors (PDC/peptide drug conjugate, RDC/metal chelating conjugate)
- Pegylated peptides
Capabilities
Advanced Peptide Synthesis Strategies
Pharmaron applies tailored synthesis strategies to balance sequence complexity, scalability and cost efficiency across peptide programs.
- Liquid Phase Peptide Synthesis (LPPS): Green chemistry approach for complex and high-payload peptides; kg‑scale production with reduced PMI and reagent excess
- Solid Phase Peptide Synthesis (SPPS): Ideal for short to medium peptides and library synthesis
- Hybrid Synthesis: Combines SPPS and LPPS for challenging sequences and cost efficiency
Peptide Synthesis Instrumentation
Pharmaron’s laboratories are equipped with diverse analytical instruments for purity control, impurity/isomers analysis, peptide mapping and API release.
- Biotage Syro II: Suitable for parallel synthesis and library synthesis (up to 25 AA residues)
- CEM Liberty Blue 2.0: Suitable for long peptides (up to 70 AA residues) and steric-hindered AA-rich peptides
- Symphony X: Suitable for peptide intermediate synthesis and gram scale synthesis
Peptide Analytical and Purification
Our analytical and purification workflows ensure rapid turnaround and reliable purity assessment for peptides at all stages.
- Rapid Method Development: Orthogonal purity checks for libraries and intermediates to confirm sequence integrity during SAR cycles
- Mini-Scale Purification: Automated prep-HPLC for fast turnaround and optimize mobile phases for complex modifications (e.g., stapled, multi-UAA)
Peptide Discovery Synthesis with High-Throughput Platforms
