Low Clearance Assay For Intrinsic Clearance

A low clearance Cl_inthigh-throughput assay using HUREL Micro Livers (Visikol) was designed to efficiently predict in vivo clearance of slowly metabolized compounds. Low clearance is essential for successful drug discovery outcomes. However, it raises challenges to determine the metabolic clearance in vitro to enable the prediction of human pharmacokinetics.

In this poster, you can find out more about:

The in vitro methodology applied to determine the in vitro clearance of slowly metabolized compounds in HUREL micro-livers
Determination of fraction unbound in the incubation (Fu_inc)
Calibration of the clearance assay to enable the prediction of in vivo human clearance by determining a regression offset
Comparison of predicted unbound Cl_int values with values derived from literature data, showing predictions within 2-fold

Name(Required)

First Last

Company Name(Required)

Job Title(Required)

Country(Required)

State(Required)

Message

Email(Required)

This field is hidden when viewing the form

Lead Source(Required)

By completing and submitting this form, you acknowledge that you have read and understood our Privacy Policy, and you consent to the collection and processing of your personal data by Pharmaron for the purpose of responding to your inquiry. You also agree to be contacted by Pharmaron regarding relevant services and updates. You may withdraw your consent at any time.