Biochemistry Services

A broad spectrum of technologies are applied to monitor target activation or reaction by evaluating protein/protein and protein/molecule binding, conformation change or substrate-to-product conversion. Pharmaron has established assays for hundreds of targets covering areas of kinase, protease, epigenetic research and more.

The team can develop biochemical assays from scratch and adapt to a high throughput screening format and characterize the compound’s mechanism of action.

Download brochure about Pharmaron’s fully automated high-throughput screening suite

Capabilities

Target Identification and Validation

in vitro Disease Biology

Targets

Kinases
Phosphatase
Proteases
HDAC and HATs
Helicase
DNA polymerases
DNA repair enzymes
Epigenetic regulatory enzymes
Metabolic enzymes
Hydrolases
E3 ligases
Deubiquitinating enzymes
Paracaspases
Aminopeptidases
GPCRs, nuclear receptors
Ion channels

Technologies

Absorbance
FI
AlphaScreen
AssayQuant
DELFIA
IMAP
TR-FRET (HTRF, Ulight, etc.)
Luminescence
ELISA/MSD
Radiochemical-based
LC/MS
ADP-Glo
Mobility shift assay

Fully Automated High Throughput Biochemical and Cell-based Screening with the Explorer G3 Suite.

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Pharmaron’s in vitro biology, in vivo pharmacology, DMPK and discovery biologics services support drug discovery and early development programs. Integration of these functions, together with laboratory chemistry, CMC and safety assessment, successfully deliver preclinical candidates and IND packages.

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Learn more about Pharmaron’s integrated drug discovery and development services

Pharmaron provides a complete integrated platform from drug discovery to proof of concept (“POC”). Our industry knowledge, strong execution tactics and end-to-end solutions shorten the drug discovery and development cycle.