Age-related Changes in Anterior Segment Biometric Measurements in New Zealand White Rabbits

Poster showing age-related changes in anterior segment biometry in NZW rabbits, highlighting the impact of age on key eye measurements in ocular research.

Poster Authors:

Sudan Puri; Vivian Trenti; James Lee; Marcela Duran; Walter Collette; Sujata Rijal; Hannah Gill; Jenny Walters; Yesica Chaparro; Stephanie Peters; Xiaohui Zhang; Sara Mangosing; Matthew Lyulkin; Sandeep Kumar; Glenwood G Gum

Ophthalmology, Pharmaron US Lab Services, San Diego, CA, United States

This study investigates how age impacts key anterior segment biometry in New Zealand White (NZW) rabbits, a commonly used model for preclinical ocular research.

Highlights from our anterior segment biometry poster:​

  • Corneal differences: Younger rabbits had thinner corneas and steeper curvature compared to older rabbits.​
  • Intraocular pressure: Higher in young rabbits (20.11 mmHg) versus older ones (18.19 mmHg).​
  • Anterior chamber volume: Significantly larger in older rabbits, while chamber depth remained similar across groups.​
  • Endothelial cells: No significant age-related differences in cell size or density.​

These findings highlight the importance of age when designing and interpreting ocular device studies in NZW rabbits.

Capabilities

Knowledge Center
Ocular Safety Assessment
Ophthalmology Animal Models
Connect with a Scientific Expert