Recorded: July 2022

This webinar will show the importance and complexity of transporter-based drug interactions.

Agenda: 

  • Drug-drug interactions involving transporter inhibition: Recent experiences with cut-off criteria
    • Overview of transporter-based DDIs
    • Cut-off criteria for OATP1B1/BCRP/P-gp/OCT2/MATEs inhibition
    • General guidance for prospective predictions
  • How do we evaluate the interactions of drugs with transporters and what are some important factors to consider?
    • Test systems and considerations
    • Optimized experimental conditions to ensure clinically relevant outcomes
    • General principles and specific case studies