Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors

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Authors: Veronica Calvo, David Surguladze, An-Hu Li, Matthew D. Surman, Srikanth Malibhatla, Madhavarao Bandaru, Suresh Krishna Jonnalagadda, Ravi Adarasandi, Madhusudhan Velmala, Durga Rama Prasad Singireddi, Mahendar Velpuri, Bhaskar Reddy Nareddy, Visweswara Sastry, Chiranjeevi Mandati, Rambabu Guguloth, Shapi Siddiqui, Basanagoud S. Patil, Elena Chad, Jennifer Wolfley, Jennifer Gasparek, Kirsten Feldman, Matthew Betzenhauser, Brent Wiens, Mary Koszelak-Rosenblum, Guangyu Zhu, Hongwen Du, Alan C. Rigby, Mark J. Mulvihill

Bioorg Med Chem Lett. 2021 Jul 1:43:128058

DOI: 10.1016/j.bmcl.2021.128058

Access the publication at:https://pubmed.ncbi.nlm.nih.gov/33895276/