Discovery of Pyrazolo[1,5‐a]pyrimidine B‐Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.

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Authors: William McCoull, Roman D. Abrams, Erica Anderson, Kevin Blades, Peter Barton, Matthew Box, Jonathan Burgess, Kate Byth, Qing Cao, Claudio Chuaqui, Rodrigo J. Carbajo, Tony Cheung, Erin Code, Andrew D. Ferguson, Shaun Fillery, Nathan O. Fuller, Eric Gangl, Ning Gao, Matthew Grist, David Hargreaves, Martin R. Howard, Jun Hu, Paul D. Kemmitt, Jennifer E. Nelson, Nichole O’Connell, D. Bryan Prince, Piotr Raubo, Philip B. Rawlins, Graeme R. Robb, Junjie Shi, Michael J. Waring, David Whittaker, Marta Wylot, Xiahui Zhu

J Med Chem. 2017 May 25;60(10):4386-4402

DOI: 10.1021/acs.jmedchem.7b00359

Access the publication at:https://pubmed.ncbi.nlm.nih.gov/28485934/