Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c] pyridin-1-yl) isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

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Authors: Abbas M Walji, Eric D Hostetler, Harold Selnick, Zhizhen Zeng, Patricia Miller, Idriss Bennacef, Cristian Salinas, Brett Connolly, Liza Gantert, Marie Holahan, Stacey O’Malley, Mona Purcell, Kerry Riffel, Jing Li, Jaume Balsells, Julie A OBrien, Stacey Melquist, Aileen Soriano, Xiaoping Zhang, Aimie Ogawa, Serena Xu, Elizabeth Joshi, Joseph Della Rocca, Fred J Hess, Joel Schachter, David Hesk, David Schenk, Arie Struyk, Kerim Babaoglu, Talakad G Lohith, Yaode Wang, Kun Yang, Jianmin Fu, Jeffrey L Evelhoch, Paul J Coleman

J Med Chem. 2016 May 26;59(10):4778-89.

DOI: 10.1021/acs.jmedchem.6b00166