Oxalate Bioanalysis Service I Pharmaron CRO

Scientific poster on oxalate quantification using hydrophilic-interaction chromatography and triple quadrupole detection, with performance data and graphs.

Poster Authors:

Robert MacNeill¹, Sridhar Swarna¹, Spundana Malla¹, Ebru Selen², Eshani Galermo², Rahul Baghla²

¹Pharmaron (Exton) Lab Services, 436 Creamery Way, Exton PA 19341

²SCIEX, 1201 Radio Road, Redwood City CA 94065

High-Performance Oxalate Quantification Using HILIC-MS Poster Overview

Presented by Pharmaron at ASMS conference, this poster highlights a cutting-edge method for oxalate quantification leveraging hydrophilic interaction chromatography (HILIC) coupled with state-of-the-art triple quadrupole mass spectrometry. The method achieves high sensitivity and precision, enabling detection down to 1 ng/mL and quantification across a 50–5000 ng/mL linear range.

Key Highlights

Robust chromatographic separation.
Calibration and quality control (QC) data demonstrating method reproducibility and accuracy at LLOQ, LQC, MQC, and HQC levels.
Optimized mass spectral detection conditions for enhanced analyte specificity.

Capabilities

Bioanalysis Services

Biomarker Assays

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Application to Oligonucleotide Analysis:

While designed for oxalate, this high-resolution HILIC-MS/MS platform is highly applicable to oligonucleotide bioanalysis. The technique’s ability to handle highly polar and negatively charged analytes, along with its fine-tuned detection sensitivity, aligns well with the complex requirements of oligonucleotide assays.

Our poster presents a case study where HILIC-MS/MS significantly enhanced oxalate biomarker quantification. This innovative workflow is poised to advance clinical and bioanalytical studies requiring precise oxalate measurement. Download the full poster to explore the methodology, data, and benefits of this state-of-the-art solution for oxalate bioanalysis.