Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid as an Excipient in mRNA-Encapsulating Lipid Nanoparticles
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Authors: Kumar Rajappan, Steven P. Tanis, Scott Roberts, Priya Karmali, Padmanabh Chivukula, Jin Zhuang, Mingxing Xin, Manman Zheng, Ian Edmonds
Org. Process Res. Dev. 2021, 25, 6, 1383–1390
DOI: 10.1021/acs.oprd.1c00076