A Novel Method for the Early, Rapid Assessment of Tissue Distribution for New Drug Candidates

Poster Authors:

Claire Henson^#, Stephen Harris^#, Gemma Bullen-Clerkson^#, Alan Lathall^#, and Jon Bloom^*

^*Pharmaron UK Ltd, The Old Glassworks, Nettlefold Road, Cardiff, CF24 5JQ; UK

^#Pharmaron UK Ltd, Pegasus Way, Crown Business Park, Rushden, NN10 6ER, UK.

With only approximately 0.1% of candidate drugs going from preclinical research to market, it is increasingly important to understand the tissue distribution of novel compounds as early in the drug development process as possible.  Elucidation of targeting, retention and accumulation properties can play a vital part in the decision to take a candidate further. The assessment of tissue distribution, however, is often a time-consuming process, involving expensive labelling, as well as complicated analyses using mass spectrometry imaging. A faster method would therefore be a great aid to drug discovery. This poster presented at ELRIG Drug Discovery 2021 gives the results of a pilot study where five commercial drugs were analyzed using a new fast and cost-effective method to assess and compare their tissue distribution.