
Achieving the Chemistry Trifecta: Efficient, Safe & Green
With every chemistry project, Pharmaron is committed to implementing innovative ways to improve efficiency, ensure the basis of safety and increase sustainability. Technologies such as high-throughput reaction screening, biocatalysis and flow chemistry are vital components to achieving these critical goals.
Our automated high throughput reaction screening platform leveraging ChemSpeed and Quantos hardware has shown excellent time-saving and optimization results for process, development and manufacturing and discovery chemistry settings. For example, the solid dispensing tool allows for solid base/additives dispensing faster and more accurately, without the need to individually weigh each vial. Pharmaron has also built custom workflows for data analysis and visualization, which allows for a rapid understanding of the optimization landscape.
Biocatalysis is an efficient and effective method to catalyze chemical reactions by using natural substances that include enzymes from biological sources or whole cells. For scale-up compound production, biocatalysis simplifies processing and purification as it generates fewer by-products, reduces steps since protecting/deprotecting isn’t required and has high stereoselection, which avoids the need for chiral separation.
Flow chemistry continues to be an effective approach for reaction selectivity. With its ability to run a reaction in a continuous stream rather than a batch production, the output is faster, more efficient and safer. We recently completed a 440kg flow chemistry campaign. After optimization, the cost decreased by 30% through increased efficiency of the process and reduction of the solvent usage by 44%.