Integrated Drug Discovery and Development
End-to-End Integrated Drug Discovery and Development (IDDD)
As a global drug discovery service provider, Pharmaron delivers integrated drug discovery and development services that accelerate programs from idea to IND filing. Our team comprises seasoned drug hunters with 20+ years of experience in biotech and pharma. We pair top-tier scientific direction with scalable access to Pharmaron’s global laboratory network of more than 22,000 professionals. Since establishing our team in 2017, we delivered over 150 projects, advanced over 70 preclinical candidates, and supported the progression of 10 molecules into clinical development.
Benefit from Pharmaron’s Renowned High-Speed DMTA Cycles
Our co‑located sites integrate design, synthesis, and testing in a single operational loop with our AI platform guiding data-driven compound prioritization and design choices to deliver highly efficient DMTA (design-make-test-analyze) cycles. Typical delivery is 3–5 days for primary assays, 5 days when including ADME, and under 10 days when in vivo PK is included. Combined with highly automated DMPK, in vitro biology, in vivo pharmacology, and structural biology our integrated workflow improves SAR and the efficiency of your drug discovery program.
Capabilities
From Target ID to IND Filing with one Team
Pharmaron provides integrated drug discovery services spanning target science, hit identification, hit-to-lead, lead optimization, preclinical candidate selection, and IND-enabling activities within a single coordinated team.
IND-Ready Tox, CMC, and Regulatory Insights to Enable a Smooth IND-Application
As part of Pharmaron’s integrated drug development services, we offer toxicology and CMC packages covering all development and manufacturing activities needed for IND submission. We assist clients directly with IND filing or collaborate with their preferred consultants to support the IND application process. In short, we help reduce pitfalls and provide a smooth path toward a successful IND application.
Platform Expertise
- DNA-encoded library screening
- High-throughput screening
- Fragment-based drug discovery Structure-based drug design
- Virtual screening
- Phenotypic screening
- AI-enabled design
Therapeutic Expertise
- Oncology
- Metabolic diseases
- Cardiovascular diseases
- Inflammation/pain
- Immunology
- Neurology
- Dermatology
- Rare diseases
Modality Expertise
- Orthosteric binders
- Allosteric binders
- Covalent binders
- Protein degraders
- Molecular glues
- Drug conjugates
Target Expertise
- Enzymes
- GPCRs
- Transporters
- Chaperones
- Nuclear receptors
- Transcription factors
- Ion channels
- Phenotypic
Our Integrated Drug Discovery Leadership Team
Pharmaron’s integrated drug discovery and development leadership team consists of seasoned drug-hunter with 20+ years of experience across biotech and pharma.
- Our team members have spent decades making high‑stakes decisions and leading programs from idea to IND filing.
- Our scientists use their experience to interrogate mechanisms, anticipate common pitfalls, and suggest experiments that change decisions.
- We leverage the AI to integrate data and generate predictive insights that guide target validation, design, and decision‑making.
- With experts based in the UK, US, and China, we provide responsive support aligned to client time zones.
True End-to-End Discovery and Development Capabilities
Our vision is to provide every capability to advance a program from initial concept to clinical evaluation. We combine deep biological insight, sophisticated chemistry, and computer-aided design.
- Target biology expertise to validate mechanisms and guide early hypotheses.
- Fast, data‑driven hit identification using diverse screening and computational design approaches.
- Efficient hit‑to‑lead optimization enabled by coordinated design, synthesis, and screening in tightly linked workflows.
- Lead optimization workflows aligned to clinical requirements incorporating human projections, PK/PD, toxicology, and developability requirements for robust candidate selection.
- IND‑enabling support, including coordinated safety, CMC, and preparation of complete regulatory packages.
Flexible Collaboration Options for Any Drug Discovery Program
Pharmaron offers flexible collaboration models, from single discipline projects to fully integrated drug discovery and development services.
- FTE‑Based Model: A dedicated scientific team works exclusively on your project, ensuring continuity and scientific ownership.
- Fee‑for‑Service (FFS): Clearly defined work packages with transparent scope, costs, and deliverables.
- Blended FTE + FFS Model: Combines strategic leadership with experimental services.
- Pilot‑to‑Platform: Low‑risk initial engagement that scales into a fully integrated drug discovery collaboration.
- Risk‑ and Milestone‑Based Model: Shared cost and risk in exchange for success milestones.
- Consultancy Services: Expert guidance available across all scientific functions.
Scientific Consulting
Some clients require expertise to navigate key scientific questions. Through our consultancy services, we offer our clients strategic input, project oversight, and interpretation of complex data.
- Strategic guidance for medicinal chemistry puts your discovery program on the right track and keeps it moving efficiently.
- CADD enables innovative solutions through modern computational techniques.
- Our DMPK experts guide ADME strategy and developability.
- Modeling and simulation predict human PK and dosing regimens, variability across populations, and toxicity risks.
- Biology consulting offers strategic guidance through mechanistic and translational biology.
Track Record of Pharmaron’s Integrated Drug Discovery and Development Team
- 150+ projects delivered over the past 9 years, including company start packages, hit‑identification campaigns, lead‑optimization programs, and in vivo proof‑of‑concept studies
- 70+ preclinical candidate packages delivered
- 10+ molecules entered clinical trials
This track record reflects the strength of our science and sustained partnerships with clients we build as a trusted drug discovery service provider.
From Idea to Clinical Trial with Industry-Leading Timelines
Our team delivers competitive timelines for integrated drug discovery and development.
Our speed is driven by four strengths:
- Seamless access to Pharmaron’s workforce capacity, instrumentation, and service portfolio
- Linking project strategy, management, and delivery all under one roof
- Program management that anticipates challenges, runs multiple workstreams in parallel, and focuses on the most informative experiments
- Use of automated workflows and the AI technology to boost efficiency
Resources Related to our Integrated Drug Discovery and Development Services
Keep up with the latest research and case studies in our Drug Discovery Webinar Series.
Our scientific leaders are serving our customers with teams in the UK, China and US.
Explore Case Studies of Pharmaron’s Integrated Drug Discovery & Development Teams
