Meet Dr. Mandy Xu
In 2018, Dr. Mandy Xu, Vice President of DMPK, celebrated her ten-year anniversary with Pharmaron. It’s a milestone that not only recognizes one of Pharmaron’s many home-grown leaders, but it also marked ten years since Pharmaron launched its DMPK services platform. These two anniversaries are not a coincidence—Mandy was hired to launch in vitro ADMET services at Pharmaron.
Now, thirteen years later both Mandy and her team continue to thrive. Since her first day at Pharmaron, Mandy has stayed focused. The tasks have changed over the years, but the end goal has remained the same, which is to provide efficient and high quality in vitro ADMET services to our partners. In her first year, she built a state-of-the-art lab, hired scientists and validated over 50 assays.
These days she leads a large research team working in in vitro ADMET that provide services for solution properties, drug absorption/transport, drug metabolism, drug-drug interactions and safety screening. Her scientists deliver high quality in vitro ADMET data to collaborators in biotech, pharmaceutical companies and academic institutions worldwide. Projects range from early drug discovery supporting PCC nomination to programs for IND/NDA submission. Mandy also leads a global team responsible for regulated bioanalysis in supporting both GLP toxicology studies and clinical sample analysis studies for small molecules.
Mandy believes her team’s success stems from striving to be chosen as our client’s partner and not solely as a service provider. Accuracy, precision and reproducibility are key elements for assessing in vitro ADMET assay quality. To achieve this high quality of assays, this group has built state-of-the-art automation capabilities and high throughput screening platforms. In addition, a carefully designed program management system was established to streamline the entire process of assays, from compound reception through assaying and data generation and interpretation, to report submission. As a result, Pharmaron is able to reduce the cycle time and provide more cost-effective solutions, providing efficient and effective services to clients.
A contributing factor to the great services provided is the culture of learning to stay updated on current science and technology. Pharmaron recently held its 2nd DMPK Symposium at its Beijing headquarters, which brought together global leaders from both industry and academia. The DMPK scientists gained important insights from each presentation and had in-depth discussions with speakers on a broad spectrum of DMPK subjects during networking times.
Mandy is proud of her team and their hard work and she feels like they are family. As the division grows, Mandy recognizes the importance of keeping the group bond strong. To celebrate their success and growth, fun events are planned each year. Just recently the fourth singing competition was held, called “ADME Voice.” Mandy is eager to plan the next fun event.
About Dr. Mandy Xu
Dr. Mandy Xu is Vice President of DMPK. She leads an in vitro DMPK research team and a global team for regulated bioanalysis in supporting both GLP toxicology studies and clinical sample analysis studies for small molecules. Dr. Xu obtained her B.Sc. and Ph.D. in Pharmaceutical Sciences from Peking University, where her studies focused on pharmacokinetics, drug distribution and excretion, in vitro drug metabolism, and metabolite identification by using LC/MSn technology. She has published over 20 research articles in peer-reviewed international journals. In her spare time, she enjoys spending time with her family and playing basketball, badminton and table tennis. She also looks forward to planning her group outings.
Updated July 2021
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