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Discovery Bioanalysis of Large Molecules

Discovery Bioanalysis of Large Molecules Services

To meet the broad needs for biologics discovery programs, Pharmaron has established a team specialized in various types of analytical technologies to analyze biologics, such as HPLC, LC/MS, Ligand-Binding Immunoaffinity (LBA) and PCR platforms. The team is highly experienced in developing new assays with various analytical platforms, with fast turnaround, to generate high-quality data to support discovery programs’ needs, for both in vitro and in vivo studies.

  • Assay development, transferred and kit-based assay optimization to support discovery bioanalysis of therapeutic biologics
  • Assay development, transferred and kit-based assay optimization for the analysis of ADA, ADCC, CDC and ADCP, TDAR and NAb, etc
  • Assay development, assay transferred and kit-based assay optimization for analysis of biomarkers of interest, including DNA and mRNA based

Capabilities

Discovery Bioanalysis of Large Molecules
Preclinical Bioanalysis of Large Molecules
Clinical Bioanalysis of Large Molecules
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Analytical Platforms

  • HPLC
  • LC/MS
  • ELISA
  • MSD
  • HELISA
  • FACS
  • Luminex
  • qPCR
  • ddPCR
  • Imaging-based methods: immunohistochemistry, liquid handling automation station
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Analytes

  • Recombinant proteins, peptides
  • Antibodies, e.g. mAbs, ADCs, PDCs, Bis-Abs, nanobodies
  • Vaccines
  • Biomarkers: DNA, mRNA and small molecule-based biomarkers
  • Fit for purpose method qualification/validation
  • Methods adapted and validated for regulated preclinical/clinical studies
  • Sample analysis for in vivo PK, PK/PD, TK assays, biomarker, immunogenicity, biodistribution studies

Learn more about Pharmaron’s large molecule bioanalytical services

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