PAST EVENT: Accelerating Discovery & Development: in vitro & in vivo ADME Optimisation

Lunch and learn held in Cambridge on Accelerating Discovery & Development: in vitro and in vivo ADME Optimisation.

Thank you for joining Pharmaron on June 25, 2025 for Accelerating Discovery & Development: in vitro and in vivo ADME Optimisation.

The field of drug discovery and development continually evolves, with a growing emphasis on understanding the absorption, distribution, metabolism, and excretion (ADME) properties of potential drug candidates. One of the most critical aspects of this process is the integration of in vitro and in vivo ADME studies (up to and including clinical phases), which offers crucial insights into the behavior of compounds and their suitability for clinical use.

Together, these studies bridge the gap between the early-stage discovery of drug candidates and their successful development into therapeutics. This event explored the latest advancements in both in vitro and in vivo ADME techniques, focusing on how these approaches can be leveraged to streamline drug development and improve the efficiency and success rates of new drug candidates. Our experts discussed emerging technologies, strategies for optimizing ADME properties, and the regulatory considerations necessary to bring safe and effective treatments to the market.

The Event Details

  • Date: June 25, 2025
  • Time: 10 am to 3.15 pm
  • Location: The Nucleus, Chesterfield Research Park, Cambridge, UK, CB10 1XL

Presentations

Discovery in vitro ADME – 2025 and Beyond

The 3Ms of PK (Miniaturisation, Microsampling and Met-ID) to support the 3Rs

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Tim Smith
Executive Director and Head of Business Development Europe, Radiolabelled Sciences
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Jack Shepherd
Business Development Associate
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Natalie Windle
Associate Director of Business Development,
Radiolabelled Sciences
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Filipa Antunes
Executive Director of Business Development
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Sidonie Aubert
Business Development, Manager
Discovery, Preclinical & CMC – Europe
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Anna Witkowska
Senior Business Development Manager
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Katherine Fenner
UK DMPK Lab lead, in vitro DMPK
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Scott Summerfield
Executive Director of Pharmaceutical Metabolism
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Helen Rollison
Principal Scientist, in vitro DMPK
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Marie Croft
Scientific Director, Radiolabelled Sciences
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Simon Teague
Senior Director, PBPK Modelling

Embracing ICH M12 – in vitro Drug-Drug Interactions in drug development

Role of AMS in Drug Development: AMS-Enabled Clinical Applications and Advances in AMS Technology

  • Marie Croft, Scientific Director for Radiolabelled Sciences

Bridging Drug Discovery and Development: The Role of PBPK Modelling in Delivering Effective Medicines

Posters

Accurate Measurement of Plasma Protein Binding for Highly Bound Compounds: Method Validation & Future Work

A Comparative Approach to Characterising Drug Metabolism using Rat Liver Microsomes and Hepatocytes

Accelerator Mass Spectrometry (AMS): Evolution of AMS and AMS-enabled Clinical Sample Analysis

Human PK Projection Strategy Incorporating Calibrated in vitro Assays and in vivo Data to Build Understanding and Confidence in our Predictions

in vivo End-to-End Process Optimisation

Optimising Discovery Metabolite Identification: Fast and Predictive in vitro Testing using HµREL®

Evaluation of ADMET Predictor as a Design, Prioritisation and ‘Tier zero’ Screening Tool in Early Drug Discovery

Accelerated Resources

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Watch on demand to explore ICH M12 updates and DDI risk prediction with Pharmaron experts.​

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