Alzheimer's Mouse Model & CRO Services For Drug Discovery

Pharmaron research highlights age-related cognitive decline and molecular differences in APP/PS1 vs. 5xFAD Alzheimer’s mouse model for drug development.

Poster Authors:

Yinjie Li, Ce Zhong, Yufang Yan, Hong Liu, Zhanshan Chen, Jing Ma, Tong Wang, Ruixiu Wang, Yarou Pu, Jingqi Huang

Pharmaron, Beijing, China

Selecting the Optimal Aβ-Driven Alzheimer’s Mouse Model for CNS Drug Discovery

This poster was presented at the SFN Neuroscience conference 2025.

Selecting the most suitable transgenic Alzheimer’s mouse model is a critical step for ensuring the translatability of preclinical findings.

In this poster we compare two widely used Aβ-driven models, APP/PS1 and 5xFAD, to help our clients make strategic decisions for their drug discovery program. Our study characterizes the age-related pathological progression in the animals through behavioral testing, histopathology, and molecular analyses, offering guidance for model selection.

Capabilities

in vitro Neurology Assay Services for Drug Discovery

CNS Disease Animal Models

iPSC-Derived Cerebral Organoids for CNS Drug Discovery

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Highlights of Our Alzheimer’s Disease CRO Services

Model-Specific Expertise: The APP/PS1 Alzheimer’s mouse model is ideal for studying gradual pathological progression, and the 5xFAD model is well suited for rapid screening of Aβ-targeting compounds.
Comprehensive Analytical Capabilities: We offer a full suite of tests, including Morris Water Maze (MWM) for cognitive deficits, immunohistochemistry (IHC) for Aβ plaque quantification, immunoassays for Aβ42 levels, and transcriptomic profiling for gene expression analysis.
Diverse Experimental Platforms: In addition to APP/PS1 and 5xFAD mice, Pharmaron’s Alzheimer’s CRO services comprise testing on other transgenic mice (3xTG, Tau P301S, Tau P301L) and utilize pharmacological approaches like scopolamine-induced amnesia, and surgical methods such as bilateral intrahippocampal Aβ1-42 injection. tTo prepare for successful in vivo studies we employ a range of in vitro models for compound testing such as brain slices, iPSC-derived neurons and organoids.

Download our scientific poster for a detailed comparison of the kinetic patterns of cognitive decline, Aβ plaque accumulation, and molecular changes in APP/PS1 and 5xFAD Alzheimer’s mouse models.