Enhanced Fragment Library For Screening Services I Pharmaron

Fragment library expansion for enhanced chemical diversity

The chemical landscape of clinical candidates and approved drugs is continually evolving. Pharmaron’s fragment library has been updated to represent these trends and to provide better starting points for medicinal chemistry campaigns. Our novel fragments are designed to increase chemical space coverage while ensuring attractive properties and high solubility. These improvements make the library ideally suited for SPR as a primary screening method, followed by orthogonal assays and structure-based development of potential hits – enabling more effective fragment-based drug discovery projects.

Key Insights of the Poster

25% library expansion with 550 carefully selected new fragments targeting underrepresented chemical space, enhancing the power of fragment library screening in your projects.
Strategic chemical space coverage prioritizing optimum physical-chemical space for high solubility and chemical tractability.
Improved hit quality from our fragment screening services demonstrated a case study with the epigenetic reader BRD4.
Rigorous quality control ensuring fragment solubility and stability through comprehensive QC workflow.

Enrichment of Pharmaron’s fragment library for improved fragment screening services

Download our poster detailing the methodology, validation studies, and performance metrics of our enhanced fragment library screening platform.

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