Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models

Accuracy of Binding Models in in vitro Metabolism Assays

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Authors: Iain Gardner, Mandy Xu, Chunyan Han, Yi Wang, Xingjin Jiao, Masoud Jamei, Hiba Khalidi, Peter Kilford, Sibylle Neuhoff, Roz Southall, David B. Turner, Helen Musther, Barry Jones, Simon Taylor

Xenobiotica. 2022 Aug;52(8):943-956

DOI: 10.1080/00498254.2022.2132426

Access the publication at: https://pubmed.ncbi.nlm.nih.gov/36222269/