High-Content Screening Services

Automated microscope-based High Content Screening (HCS, or HCA, HCI) is utilized at Pharmaron to study multiple features simultaneously within complex biology systems at the single cell, 3D spheroid and organoid level. High-content screening is routinely applied at Pharmaron to improve the screening workflows of our clients, saving time and resources by observing and simultaneously analyzing cellular events.

Pharmaron’s dedicated in-house bioinformatics team helps our clients manage, analyze and interpret large datasets to enable data-driven decision-making. High-Content Screening systems enable real-time monitoring to gain an even deeper understanding of the phenotypic changes in the cells by adding time as an additional dimension.

Pharmaron’s cell biology experts collaborate closely with our genomics and proteomics specialists to systematically explore complex biological phenomena within cellomics, contributing to our comprehensive morphological profiling capabilities.

A variety of applications are supported by high content imaging at Pharmaron:

• Hit Identification: Efficiently narrow down a compound library to a selection of promising compounds based on their performance in cells.
• Drug Mechanism: Provide deep insights into cellular mechanisms and phenotypic effects induced by novel test articles . 
• Multiplexed Phenotypic Readouts: Enhance screening efficiency through the simultaneous execution of multiple assays.
• Cell Painting: Implementing an unbiased approach to phenotypic drug discovery via the simultaneous staining of various cell organelles and morphological features.

High-content screening can be performed at Pharmaron in low and high throughput modes with fully automated workflows for systematic and economic compound screening. To understand how this exciting technology and our expertise in morphological profiling can advance your drug discovery project, please reach out to talk to one of our scientists.