How Biophysics aids Drug Discovery
Biophysical techniques are employed across all stages of drug discovery.
In this poster, we outline the solutions offered by the biophysics capabilities at Pharmaron enabling efficient prioritization and advancement of the most promising molecules. We will present case studies for small and large molecule as well as protein degrader characterization.
Methods Presented in the poster:
- SPR: Investigation of targeted protein degraders
- MST: Characterizing binding events
- nanoDSF: Optimizing in vitro assay conditions
- ITC: Thermodynamic parameters of a binding event
- BLI: Epitope binning for monoclonal antibody discovery
- Mass spec: Peptide mapping analysis for covalent binders