Publications

DNA-encoded Chemistry: Enabling the deeper sampling of chemical space

Goodnow, R. A., Jr., Dumelin, C. E., Keefe, A. D., Nature Reviews Drug Discovery, 2017, 16, 131-147

Publications

Structure-based design of tricyclic NF-κB inducing kinase (NIK) inhibitors that have high selectivity over phosphoinositide-3-kinase (PI3K)

Castanedo, G*; Blaquiere, N; Beresini, M; Bravo, B; Brightbill, H; Chen, J; Cui, H, Eigenbrot, C; Everett, C; Feng, J; Godemann, R; Gogol, E; Hymowitz, S†; Johnson, A; Kayagaki, N; Bir Kohli, P; Knüppel, K; Kraemer, J; Krüger, S; Loke, P; McEwan, P; Montalbetti, C; Roberts, D; Smith, M; Steinbacher, S; Sujatha-Bhaskar, S; Takahashi, R; Wang, X; Wu, L; Zhang, Y; and Staben, S. J Med Chem, 2017, 61(15), 6801-6813.

Publications

Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs).

Walji, A. M; Hostetler, E. D; Selnick, H; Zeng, Z; Miller, P; Bennacef, I; Salinas, C; Connolly, B; Gantert, L; Holahan, M; O’Malley, S; Purcell, M; Riffel, K; Li, J; Balsells, J; Obrien, J. A; Melquist, S; Soriano, A; Zhang, X; Ogawa, A; Xu, S; Joshi, E; Della Rocca, J; Hess, F. J; Schachter, J; Hesk, D; Schenk, D; Struyk, A; Babaoglu, K; Lohith, T. G; Wang, Y; Yang, K; Fu, J;Evelhoch, J. L; Coleman, P, J. J Med Chem, 2016, 59, 4778-4789.

Publications

Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor ROR.

Olsson, R; Xue, Y; von Berg, S; Aagaard, A; McPheat, J; Hansson, E; Bernstrçm, J; Hansson, P; Jirholt, J; Grindebacke, H; Leffler, A; Chen, R; Xiong, Y; Ge, H; Hansson, T; Narjes, F. ChemMedChem, 2016, 11, 207-216.

Publications

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

Volgraf, M; Sellers, B; Jiang Y; Wu, G; Ly, C; Villemure, E; Pastor, R; Yuen, P; Lu, A; Luo, X; Liu, M; Zhang, S; Sun, L; Fu, Y; Lupardus, P; Wallweber, H; Liederer, B; Deshmukh, G; Plise, E; Tay, S; Reynen, P; Herrington, J; Gustafson, A; Liu, Y; Dirksen, A; Dietz, M; Liu, Y; Wang, T-M; Hanson, J; Hackos, D; Scearce-Levie, K; Schwarz, J; J Med Chem, 2016, 59, 2760-2779.