Virtual Lecture: Molecular Editing via Direct C-H Functionalization – From Precious Metal Catalysis to Base Metal Catalysis
Lecture held on: December 28
Presenter
Prof. Bingfeng Shi – Department of Chemistry, Zhejiang University
In this lecture, Prof. Bingfeng Shi discussed the transition metal catalyzed direct functionalization of unactivated C-H bonds that has emerged as a powerful strategy to build up structural complexity from readily available hydrocarbon feedstocks. Prof. Bingfeng Shi is deeply involved in the development of new C-H activation reactions and their synthetic applications. He has developed novel methods on the highly efficient and enantioselective functionalization of C-H bonds catalyzed by palladium catalysts, which have been successfully applied to the total synthesis of several types of natural products. Recently, considering the earth abundance, inexpensiveness, and, most importantly, the unique and versatile reactivity of cobalt catalysts, Prof. Bingfeng has engaged in the development of cobalt catalyzed enantioselective C-H functionalization reactions. He has developed three novel types of cobalt catalysis, namely, achiral CpCo(III)/chiral carbonyl acid (CCA), Co(II)/chiral spiro phosphoric acid (SPA) cooperative catalysis, and Co(II)/salicyloxazoline (Salox) which enable the highly enantioselective synthesis of chiral molecules bearing planar chirality, axial chirality, C- and P- stereogenic centers. The modular and asymmetric synthesis of THIQ alkaloids and API intermediates have also been achieved.