
Virtual Lecture: Oxygen Driven Fragment Coupling for the Synthesis of Natural Products and Antibacterials
Lecture held on: March 28
Presenter
Prof. Marisa Kozlowski – Department of Chemistry, University of Pennsylvania
In this lecture, Prof. Marisa Kozlowski discussed the use of parallel microscale screening to discover selective and efficient catalysts using oxygen as the terminal oxidant. The unexpected outcomes obtained highlight the value of interrogating large numbers of rationally selected variables under the umbrella of general hypothesis. The development of selective oxidative catalytic processes for phenol coupling, enol coupling, and alkyl C-H activation was discussed. Applications in total synthesis of hypocrellin honokiol chaetoglobin and pyrolaside B was presented. Finally, studies on the mechanisms of these transformations were described with the goal of understanding the governing principles and how they might be used to discover further new transformations.