Virtual Lecture: Applied Late stage Functionalization: Where Chemistry Meets Biology C-H Activation for Late-Stage Diversification of Biomolecules
Lecture held on: August 31, 2023
Presenter
Prof. Lutz Ackermann – Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Göttingen, Germany
The continuously increasing demand for complex molecular scaffolds in biology and material sciences, as well as agrochemical and pharmaceutical industries translates into a continued strong demand for innovative molecular syntheses. Non-natural peptides have emerged as increasingly potent scaffolds in medicinal chemistry and the pharmaceutical industry. As a consequence, the chemoselective assembly and modification of structurally complex peptides continues to be of utmost importance. Significant recent momentum was gained through the development of palladium catalyzed cross couplings of peptides. A significantly more atom- and step-economic strategy relies on the direct activation of otherwise unreactive C-H bonds, with recent transformative applications towards peptide modification. As part of our program on sustainable C-H activation, we have unraveled new methodologies that allow the expedient functionalization of not only peptides, but also carboranes, saccharides, and complex drug molecules based on sustainable C-H activation.