DMPK Studies for R&D Efficiency
Pharmaron’s DMPK service helps our partners improve their drug R&D efficiency through comprehensive DMPK studies and our integrated discovery, preclinical, and clinical DMPK platforms.
Pharmaron works together with our partners to develop new assays, conduct DMPK studies and investigations to support innovative ideas and establish a better model for drug screening and study. In addition, we support IND submission reports, provide clinical research to support phase l and ll clinical trials and offer clinical sample bioanalysis.
AstraZeneca recently published two papers on drug metabolism and disposition focused on predicting in vivo clearance and plasma concentration for a range of flavin-containing monooxygenase substrates. Pharmaron performed a series of in vitro hepatic stability and protein binding assays, which helped support this work.
Drug Metab Dispos, 46 (9) 1259-1267, September 2018
Drug Metab Dispos, 45 (10) 1060-1067, October 2017
Written with permission by AstraZeneca
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