Disposition of Radiolabelled Biologics

With many years of experience performing large molecule ADME studies, Pharmaron’s biologics team conducts studies for a diverse range of large molecules, including peptides, proteins, ADCs, fusion proteins and oligonucleotides.

We have a wide range of radiolabelling options depending on the nature of the large molecule, including direct radiochemical synthesis techniques 14C and our 3H-labelled protein, peptides, polymers, oligonucleotides and ADCs.

The ADME portfolio of services performed at our facility include tissue distribution assessments using combinations of QWBA and MARG and have been extended to include pharmacology models, most notably a wide range of xenograft and syngeneic (allograft mouse tumor stems) models.

Pharmaron is also able to support the disposition of potent biologics with ultrasensitive quantitative AMS analysis of 14C radiolabelled biologics.

3H and 14C Radiolabels (RadioTag) 14C Radiolabels and AMS for Biologics

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