Non-clinical ADME with Radiolabelled Compounds

Pharmaron supports non-clinical compound development. Non-clinical ADME in our Rushden UK facility includes the following: pharmacokinetics, excretion balance, tissue distribution, biliary excretion, metabolite analysis (metabolite profiling/MetID), placental transfer, milk secretion, bioanalytical support, QWBA with disease models and dosimetry calculation for radiolabelled clinical metabolism studies.

We provide AMS technology to support ultra-sensitive quantitative analysis for non-clinical ADME studies with ¹⁴C-substances. Non-clinical ADME studies are typically performed in the appropriate tox species, however these studies can be extended into a wide range of pharmacology models, including oncology, CNS, cardiovascular and metabolic disease, inflammation and pain models.

in vitro Metabolism with Radiolabelled Compounds in vivo PK Using Radiolabelled Compounds Tissue Distribution with QWBA and MARG