Target Identification and Validation
Target Identification and Validation Services
Pharmaron is able to utilize multiple approaches to identify and characterize promising therapeutic targets. The team is continuously developing new tools and technologies to validate targets more efficiently, positioning promising leads at the beginning of a drug development projects.
Our team has in-depth experience with gene/RNA editing by different methods from single gene to genome-wide, followed by powerful bioinformatics, pathway analysis and biological functional analysis. In addition, chemoproteomics and mass spectrometry were also established for target engagement and deconvolution by utilizing new chemical probes and screening platforms.
Capabilities
Target Identification and Validation
- siRNA knockdown (library or single gene)
- shRNA knockdown
- CRISPR-Cas knockout
- Genome-level CRISPR library screening
- Pathway-focused CRISPR screening
- CRISPR-Cas knock In for disease-relevant mutation
- CRISPR-Cas knockin tagging of endogenous protein
- Inducible expression system of gene manipulation
- Constitutive overexpression system
- Chemoproteomics
